The USEPA acknowledges that human data are insufficient to demonstrate that EtO causes any cancer in humans (e.g., lymphoid or breast cancer), even in workers exposed to levels up to millions of times higher than environmental levels to which the general U.S. population may be exposed. They threw out the EPA’s conclusion that cancer risks from ethylene oxide increase dramatically at lower levels of exposure and flatten out at higher concentrations. ETHYLENE OXIDE and OXIRANE Cancer Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Tumor type(s): Lymphoid cancer, (female) breast cancer (Steenland et al., 2003, 2004) Note: ADAF -- EPA has concluded that ethylene oxide is carcinogenic by a mutagenic mode of action. Ethylene oxide (EO), a direct alkylating agent and a carcinogen, can attack the nucleophilic sites of DNA bases to form a variety of DNA adducts. Basis for listing ethylene oxide as known to the State to cause developmental toxicity, male reproductive toxicity, and female reproductive toxicity changed from Labor Code to 'Formally Required to Be Labeled or Identified' effective November 22, 2013. You may have a cancer claim for monetary damages caused by the medical plant that released the toxic ethylene oxide into the air. Vincent MJ(1 Ethylene oxide has been produced by a Swedish company since the beginning of the 1940s. “Cancer incidence and mortality in Swedish sterilant workers exposed to ethylene oxide: updated cohort study findings 1972-2006.” International Journal of Environmental Research and Public Health 8, 6 (2011): 2009-19. Cancer in Humans Epidemiological evidence of the risk for human cancer from ethylene oxide derives principally from the follow-up of 14 cohorts of exposed workers, either in chemical exposed to ethylene oxide for more than 10 years (Teta et al. I know something about ethylene oxide. ATLANTA — Another metro Atlanta company has been accused of - and fined for - spewing the cancer-causing gas ethylene oxide into the air. Studies show that long-term, occupational exposure to high levels of ethylene oxide increases the risk of breast cancer in women. Chronic exposure to ethylene oxide is also mutagenic. There is minimal cancer risk for the general population because most people are not exposed to significant quantities of ethylene oxide. Suppose you’ve ever heard of ethylene oxide. For decades, ethylene oxide (ETO) has attracted considerable research interest as a direct alkylating agent and likely human carcinogen. Two other federal agencies are against it, citing cancer … See how people are Spreading Smiles across the Tennessee Valley NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. 1. This page contains the Ethylene Oxide DSD and background for the review. There is no single cause of, or risk factor for, breast cancer. In recent years, the EPA updated its classification for ethylene oxide from "Likely to cause cancer" to "Definitely causes cancer." Elevated levels of the cancer-causing compound ethylene oxide were found in the air around two industrial plants last year near Smyrna and Covington. 1993) and elevated incidence of breast cancer in a cohort of workers who used ethylene oxide as a … Well for starters, the National Cancer Institute describes the chemical used for it, ethylene oxide, as being “highly explosive and reactive” and they categorize it under cancer-causing substances (). Is the evidence for its carcinogenicity conclusive? Abstr. Background: Ethylene oxide (ETO) is a sterilant gas considered to be a human carcinogen, due primarily to excess hematopoietic cancer in exposed cohorts. Ethylene oxide is an alkylating agent; it has irritating, sensitizing and narcotic effects. eCollection 2019 Oct-Dec. Articles from Occupational and Environmental Medicine are provided here courtesy of BMJ Group 2019 Dec 11;17(4):1559325819888317. doi: 10.1177/1559325819888317. After meeting with Trump, Medline wants FDA approval to sterilize N95 masks with ethylene oxide. International Agency for Research on Cancer (IARC) - Summaries & Evaluations ETHYLENE OXIDE (Group 1) For definition of Groups, see Preamble Evaluation. Mikoczy, Zoli et al. Method: Cancer incidence through 31 December 1987 was ascertained in a cohort of 1132 individuals employed at the worksite at any time from 1 July 1974 through 30 September 1980, the period of potential exposure to ETO at the plant. Ethylene oxide (EtO) is a highly reactive chemical used as a sterilizing agent and a feedstock for producing other chemicals. Ethylene Oxide: Cancer Evidence Integration and Dose-Response Implications. Name: Oxirane 2. Sterilization Services … • Ethylene oxide has been shown to cause lymphoid cancer and tumors of the brain, lung, connective tissue, uterus, and mammary gland in animals exposed to ethylene oxide by inhalation. Residents near … Is my breast cancer caused by ethylene oxide? with ethylene oxide (IPCS-CEC, 2001). Ethylene oxide emissions by Vantage Specialty Chemicals in Gurnee and Medline in Waukegan are unacceptable. The International Agency for Research on Cancer classifies ethylene oxide into group 1. (1) • … Ethylene oxide pollution has raised cancer risks for more than half a million people across the country, according to a Chicago Tribune analysis of EPA data. Ethylene oxide is used extensively in chemical manufacturing, agriculture, and fumigation, but it is extremely hazardous. The Occupational Safety and Health Administration’s (OSHA) ethylene oxide standard requires employers where ethylene oxide is present in the workplace to monitor employee exposure . VOL. 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